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Prozac sexual side effects: can they last?

Prozac (fluoxetine) commonly lowers sex drive and may affect orgasm. The UK leaflet warns this has sometimes continued after stopping. That is called PSSD.

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By Morten SkovPublished Updated
Poster: “Prozac sexual side effects: can they last?” with Prozac’s US label saying symptoms “occasionally persist” after stopping.

Prozac (fluoxetine) commonly lowers sex drive and can cause erection and orgasm problems. The UK fluoxetine leaflet warns these problems have sometimes continued after stopping, a condition known as post-SSRI sexual dysfunction, or PSSD.

PSSD is more than a sex problem, even though the name says so. Doctors and researchers who proposed criteria for PSSD in 2022 put a lasting change in genital sensation at its core, often numbness, and also list emotional numbing, problems with thinking and changes in other senses.

The NHS page on fluoxetine lists low sex drive but doesn’t mention that it can continue after stopping. That’s worth knowing before your first capsule, and worth reporting if you’ve stopped and sex still feels different.

The story in 3 lines

  1. The UK leaflet lists a lower sex drive and erection problems as common side effects of fluoxetine.
  2. Prozac’s own US label has said since 2011 that these symptoms “occasionally persist” after stopping.
  3. No reliable figure exists for how often (2023 review). Patients call it PSSD.

Press: contact@sidefxhub.com

Katie was 21 and going through a difficult time when she was prescribed Prozac. She took it for about three years.

Katie, interviewed by Moral Medicine, May 2026. If you’re struggling, the Samaritans are on 116 123 in the UK.

Watch it for what PSSD can feel like from the inside, beyond the leaflet’s short list. She describes emotional blunting and sexual problems, and losing the ability to feel attraction. It took her a long time to see that it began with the medicine. She has lived with it for about 14 years, most of them after her last capsule.

How common are Prozac’s sexual side effects?

Common, says the UK leaflet, and they seem to turn up more often when someone actually asks. Prozac’s US label says its own figures probably undercount them, partly because patients and doctors may be reluctant to talk about sex.

One trial did ask. Trained staff checked sexual function at every weekly visit. In the published results, about 3 in 10 people on fluoxetine had orgasm problems after eight weeks, against about 1 in 10 on a dummy pill.

These side effects can mean wanting sex less. For some, it’s an erection that won’t last, or an orgasm that takes much longer or never comes.

Can Prozac’s sexual side effects last after stopping?

Yes, for some people. The UK leaflet says that in some cases, these symptoms “have continued after stopping treatment”.

The warning isn’t new. Prozac’s maker asked to add a line like it to its US label in 2011, and the US regulator approved it. The label still says the symptoms “occasionally persist after discontinuation”.

No reliable figure exists for how often it happens. A 2023 review of the research couldn’t find one.

For some people it has lasted years after stopping. Nobody knows yet who will be affected, or whether it will ease.

Joanna Moncrieff, a professor of psychiatry at UCL, says these effects have been reported for months and even years, and that many doctors may not know about them. Her 90-second clip is general background on PSSD, not about Prozac alone, and useful if your GP hasn’t heard of it.

Professor Joanna Moncrieff on post-SSRI sexual dysfunction (PSSD). Posted by the PSSD Network, June 2026, 90 seconds.

Could it just be fluoxetine still in my body?

For the first few weeks, it could be. Fluoxetine leaves the body slowly. Prozac’s US label says the active drug “will persist in the body for weeks” after the last dose, so side effects can carry on for a while.

Months or years are a different matter. The 2022 criteria, which are proposed criteria rather than an official diagnosis, say that once problems last three months after stopping, it’s more likely to be PSSD. Their key symptom is a lasting change in how the genitals feel, such as numbness.

Numbness was reported early on. In 1991 a doctor wrote to the American Journal of Psychiatry about a numb penis in a man taking fluoxetine.

Fluoxetine after the last capsule

Last capsule
The drug starts to leaveLevels in the blood fall slowly.
First weeks
Still in the bodySide effects may simply carry on.
Three months
The PSSD criteria can applyIf the problems are still there.
Years later
The drug is long goneFor some people, the symptoms remain.
Sources: Prozac US label; Healy and colleagues, 2022.

What can I do?

These medicines help many people. If you have side effects, that’s a decision for you and your prescriber. Don’t stop suddenly.

If the problems haven’t lifted since you stopped, tell your GP and give your dates: “Fluoxetine 20 mg from January 2023, last capsule March 2024.” Note what changed, including changes beyond sex, such as feeling emotionally flat or struggling to think clearly, and how things were before.

Three questions for your GP

  1. Could these be lasting effects of fluoxetine, as the leaflet describes?
  2. What else should we rule out, and how?
  3. Can this go on my record and be reported to the Yellow Card scheme?

You could start with: “The fluoxetine leaflet says sexual problems have sometimes continued after stopping. I think that's happening to me.”

Many people say it took time to be taken seriously. Bring the leaflet line. You can report it without a doctor agreeing.

Report it: it helps everyone

A doctor’s note helps you. A report to the medicines regulator helps everyone else: it is how patterns get noticed.

  • No proof needed. A suspicion is enough, even years after stopping.
  • Where: the Yellow Card scheme in the UK, MedWatch in the US.
  • Use the right words. If symptoms continued after stopping, write Post-SSRI sexual dysfunction (MedDRA 10086208).

Our reporting guide walks you through it

What else do people ask?

Could it be my depression? It can play a part: a 2026 paper by New Zealand’s medicines regulator notes that depression itself often lowers sex drive. The PSSD criteria ask what sex was like before the medicine. Prozac’s US label also tells doctors to ask when the problems began.

Does Prozac affect women too? Yes, Prozac’s US label says it can cause sexual problems in women as well as men. An early report, a 1993 letter to a psychiatry journal, described vaginal numbness on fluoxetine. Our article on PSSD in women covers what is known so far.

What about teenagers? The UK leaflet says fluoxetine can be used for depression from the age of 8. For under-18s, it adds that it “may slow growth or possibly delay sexual maturity”. As the 2022 criteria point out, someone who starts before puberty may have no “before” to compare with, which is a reason to talk about sex with the prescriber from the start.

Katie spent years believing something was wrong with her. If sex has felt different ever since your last capsule, report it: a report counts even years later.

Sources

  1. Fluoxetine 20 mg Capsules, patient leaflet, Electronic Medicines Compendium (EMC 15755), revised September 2022. Section 1, use in children and adolescents aged 8 and above; section 2, “Sexual dysfunction”; section 4, common and uncommon side effects (among the uncommon ones: sexual problems “occasionally persisting after treatment discontinuation”), and side effects in children and adolescents aged 8 to 18.
  2. Prozac (fluoxetine), US prescribing information and Medication Guide, revised August 2023. DailyMed, US National Library of Medicine. Section 6.1 (persistence after discontinuation; figures likely to underestimate actual incidence), section 5.17 (sexual dysfunction in male and female patients; history including timing of symptom onset), sections 5.14 and 12.3 (elimination half-lives; active drug persists for weeks after dosing stops). The sentence on persistence stands among the adverse reactions, not in a warning, and the Medication Guide does not have it.
  3. US Food and Drug Administration, supplement approval letter, NDA 18-936/S-096, 15 June 2011. Eli Lilly’s application was dated 8 April 2011.
  4. NHS, Fluoxetine, page last reviewed 1 June 2026.
  5. Coleman CC, King BR, Bolden-Watson C and colleagues. A placebo-controlled comparison of the effects on sexual functioning of bupropion sustained release and fluoxetine. Clin Ther 2001;23(7):1040-58. Results summary: GSK study register, AK1A4007. Orgasm dysfunction at day 56: 45 of 146 people on fluoxetine (31%), 16 of 145 on placebo (11%). Sponsored by the maker of bupropion; eight weeks, during treatment only.
  6. Tarchi L, Merola GP, Baccaredda-Boy O and colleagues. Selective serotonin reuptake inhibitors, post-treatment sexual dysfunction and persistent genital arousal disorder: a systematic review. Pharmacoepidemiol Drug Saf 2023;32(10):1053-67.
  7. Healy D, Bahrick A, Bak M and colleagues. Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin. Int J Risk Saf Med 2022;33(1):65-76.
  8. Neill JR. Penile anesthesia associated with fluoxetine use. Am J Psychiatry 1991;148(11):1603.
  9. King VL Jr, Horowitz IR. Vaginal anesthesia associated with fluoxetine use. Am J Psychiatry 1993;150(6):984-5.
  10. Medsafe, Update on sexual dysfunction following discontinuation of serotonin reuptake inhibitors, paper for the Medicines Adverse Reactions Committee, 11 June 2026. Section 2.2.1, sexual dysfunction in depression.
  11. Moral Medicine, I Lost My Sexual Identity After Prozac, interview with Katie, May 2026. Her story on our site: Katie’s story: 14 years after Prozac.
  12. PSSD Network, Professor Joanna Moncrieff discusses Post-SSRI Sexual Dysfunction, June 2026.

This information does not replace medical advice. Talk to your doctor before you make any decision about your treatment.

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Fluoxetine: what the official texts say, country by country

For the SSRI antidepressant fluoxetine (Prozac), the product information we read in the United Kingdom, that of a generic product, says there have been reports of long-lasting sexual dysfunction where symptoms continued after SSRIs were stopped. This is known as post-SSRI sexual dysfunction (PSSD). The EU medicines regulator set the wording of this warning in 2019 for ten medicines, fluoxetine among them, and a government answer in Parliament says UK product information for all SSRIs was updated in 2019 to carry it. In the United States, the Prozac text for professionals says that symptoms of sexual dysfunction occasionally persist after fluoxetine is stopped. That sentence stands in the section on adverse reactions, not in a warning, and not every fluoxetine label there has it.

This is a record of what each text says and of the date it prints. A text is quoted in its own words, or summarised where the row says so. It is not a comparison of countries. All medicines and countries

Fluoxetine: the official texts, country by country (36 texts read)
Fluoxetine: what each text says about sexual side effects, and about side effects that continue after stopping.
Country or regionWhat the text saysDocumentDates
United Kingdom

Sexual side effects that continue after stopping4.4 Special warnings and precautions for use · Sexual dysfunctionSelective serotonin reuptake inhibitors (SSRI) may cause symptoms of sexual dysfunction (see section 4.8). There have been reports of long-lasting sexual dysfunction where the symptoms have continued despite discontinuation of SSRIs.On record since 2019, according to a government answer in parliament, 13 May 2025. That document is about the whole class of medicines. It does not name fluoxetine.

Sexual side effects, as listed4.8 Undesirable effects · b) Tabulated list of adverse reactions · Psychiatric disorders · CommonAnxiety Nervousness Restlessness Tension Libido decreased3 Sleep disorder Abnormal dreams4

Sexual side effects, as listed4.8 Undesirable effects · b) Tabulated list of adverse reactions · Psychiatric disorders · UncommonDepersonalisation Elevated mood Euphoric mood Thinking abnormal Orgasm abnormal5 Bruxism Suicidal thoughts and behaviour 6

Sexual side effects, as listed4.8 Undesirable effects · b) Tabulated list of adverse reactions · Reproductive system and breast disorders · CommonGynaecological bleeding14 Erectile dysfunction Ejaculation disorder15

Sexual side effects, as listed4.8 Undesirable effects · b) Tabulated list of adverse reactions · Reproductive system and breast disorders · UncommonSexual dysfunction16

Sexual side effects that continue after stopping4.8 Undesirable effects · b) Tabulated list of adverse reactions · footnote 16Occasionally persisting after treatment discontinuation

Sexual side effects, as listed4.8 Undesirable effects · b) Tabulated list of adverse reactions · Reproductive system and breast disorders · RareGalactorrhoea, Hyperprolactinaemia Priapism

The same text also says4.8 Undesirable effects · a) Summary of the safety profileUndesirable effects may decrease in intensity and frequency with continued treatment and do not generally lead to cessation of therapy.

Sexual side effects, as listed4.8 Undesirable effects · d) Paediatric populationIsolated cases of adverse events potentially indicating delayed sexual maturation or sexual dysfunction have been reported from paediatric clinical use (see also section 5.3).

The originator product is not in the list we read. This is another product from that list.

Texts for other products in this country do not all say the same. We searched them for sentences about sexual side effects continuing after stopping and did not read them whole. This row shows the product named, and no other.

A table cell or list line is shown whole, as the text prints it. Some of them also name side effects that are not sexual.

Text for professionals Summary of Product Characteristics (SmPC): Fluoxetine 10 mg hard capsulesFluoxetine 10 mg hard capsules, Brown & Burk UK Ltd · Read in a compendium of product information: emcAlso on record: patients' leaflet, with such a sentence; 3 related documents, with such a sentenceText revisedChecked
European Union

Sexual side effects that continue after stopping3. Serotonin and noradrenaline reuptake inhibitors (SNRI); selective serotonin reuptake inhibitors (SSRI) – Persistent sexual dysfunction after drug withdrawal (EPITT no 19277) · Summary of product characteristics · 4.4. Special warnings and precautions for use · Sexual dysfunctionThere have been reports of long-lasting sexual dysfunction where the symptoms have continued despite discontinuation of SSRIs/SNRI.On record since 2019, according to EMA, 11 June 2019.

Sexual side effects that continue after stopping3. Serotonin and noradrenaline reuptake inhibitors (SNRI); selective serotonin reuptake inhibitors (SSRI) – Persistent sexual dysfunction after drug withdrawal (EPITT no 19277) · Package leaflet · 2. What you need to know before you take [Invented name] · Warnings and precautionsIn some cases, these symptoms have continued after stopping treatment.On record since 2019, according to EMA, 11 June 2019.

The wording is for ten medicines: citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, desvenlafaxine, duloxetine, milnacipran and venlafaxine.

This is wording for national product texts. There is no single EU product text for this medicine.

Document from the regulator New product information wording – Extracts from PRAC recommendations on signals. Adopted at the 13-16 May 2019 PRACRead on the regulator's site: European Medicines AgencyAlso on record: 1 more related document, with such a sentencePublishedChecked
United States

Sexual side effects, as listed5 WARNINGS AND PRECAUTIONS · 5.17 Sexual DysfunctionUse of SSRIs, including PROZAC, may cause symptoms of sexual dysfunction [see Adverse Reactions (6.1)]. In male patients, SSRI use may result in ejaculatory delay or failure, decreased libido, and erectile dysfunction. In female patients, SSRI use may result in decreased libido and delayed or absent orgasm.

The same text also says5 WARNINGS AND PRECAUTIONS · 5.17 Sexual DysfunctionWhen evaluating changes in sexual function, obtaining a detailed history (including timing of symptom onset) is important because sexual symptoms may have other causes, including the underlying psychiatric disorder.

Sexual side effects that continue after stopping6 ADVERSE REACTIONS · 6.1 Clinical Trials Experience · Male and female sexual dysfunction with SSRIsSymptoms of sexual dysfunction occasionally persist after discontinuation of fluoxetine treatment.In this product's text since 2011, according to FDA, 15 June 2011.

The same text also says6 ADVERSE REACTIONS · 6.1 Clinical Trials Experience · Male and female sexual dysfunction with SSRIsThere are no adequate and well-controlled studies examining sexual dysfunction with fluoxetine treatment.

The date given is for this product. Texts for other products carry other dates.

An official list of medicines we read shows this product as discontinued or no longer marketed, and the text in this row is still this product's own.

This text names sexual side effects in several places that this row does not show. Together those passages are too long to reproduce here. The document link in this row opens the text. That they are not shown says nothing about how common these side effects are.

On 14 October 2026 we searched the labels in openFDA, the FDA's open database. The sentence about sexual dysfunction persisting after stopping, which this row shows, stood on 388 of the 439 labels in that database that contain fluoxetine. Five of the 388 are labels of the combination of olanzapine with fluoxetine. On those 388 labels the sentence stood among the adverse reactions and in no warnings section.

Text for professionals PROZAC (fluoxetine capsules) for oral use: Full Prescribing InformationProzac capsules ("Pulvules") 10 mg, 20 mg and 40 mg, Dista Products Company · Read in the government's medicines database: DailyMedAlso on record: patients' leaflet, with no such sentence; related document, with such a sentenceText revisedChecked
Canada

Sexual side effects that continue after stopping7 WARNINGS AND PRECAUTIONS · Reproductive Health: Female and Male Potential · FunctionSelective serotonin reuptake inhibitors (SSRIs) may cause symptoms of sexual dysfunction (see 8.2 Clinical Trial Adverse Reactions). Patients should be informed that there have been reports of long-lasting sexual dysfunction where the symptoms have continued despite discontinuation of SSRIs.

Sexual side effects that continue after stopping8 ADVERSE REACTIONS · 8.2 Clinical Trial Adverse Reactions · Male and Female Sexual Dysfunction with SSRIsSymptoms of sexual dysfunction occasionally persisting after discontinuation of fluoxetine treatment have been observed in spontaneous reports.

The same text also says8 ADVERSE REACTIONS · 8.2 Clinical Trial Adverse Reactions · Male and Female Sexual Dysfunction with SSRIsThere are no adequate and well-controlled studies examining sexual dysfunction with fluoxetine treatment.

An official list of medicines we read shows the originator product as cancelled, revoked or archived. This is the text of another product, the one named in this row.

This text names sexual side effects in several places that this row does not show. Together those passages are too long to reproduce here. The document link in this row opens the text. That they are not shown says nothing about how common these side effects are.

Text for professionals PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION INFORMATION: APO-FLUOXETINE, Fluoxetine Capsules, Fluoxetine Oral SolutionAPO-FLUOXETINE capsules 10 mg and 20 mg and oral solution 20 mg/5 mL, Apotex Inc. · Read in the regulator's own database: Drug Product DatabaseAlso on record: patients' leaflet, with such a sentence; 2 related documents, with such a sentenceText revisedChecked
Australia

Sexual side effects that continue after stoppingSection 4.4 · Sexual dysfunctionSection 4.4 of Australia's product information for APO-Fluoxetine has a warning headed sexual dysfunction. It says there are reports of sexual dysfunction that lasted a long time, with symptoms going on after SSRIs or SNRIs were stopped.Summarised, not quoted, because of the TGA's access terms.

Sexual side effects that continue after stoppingSection 4.8 · Urogenital System · UncommonIn section 4.8, the list of side effects of the urogenital system has sexual dysfunction among the uncommon ones, and adds in brackets that it occasionally persists after treatment is stopped.Summarised, not quoted, because of the TGA's access terms.

The regulator's site asks readers to accept its terms before it shows this text.

The originator product is not in the list we read. This is another product from that list.

Text for professionals AUSTRALIAN PRODUCT INFORMATION APO-FLUOXETINE (FLUOXETINE HYDROCHLORIDE)APO-FLUOXETINE, Arrotex Pharmaceuticals Pty Ltd · Read in the regulator's own database: TGA eBSAlso on record: patients' leaflet, with such a sentenceText revisedChecked
New Zealand

Sexual side effects, as listed4.8 Undesirable effects · b. Adverse reactions from clinical trials · Nervous system disorders · Commonabnormal dreams, libido decreased, sleep disorder, thinking abnormal, chills;

Sexual side effects that continue after stopping4.8 Undesirable effects · b. Adverse reactions from clinical trials · Reproductive system and breast disordersCommon: abnormal ejaculation (male only), gynaecological bleeding (female only), impotence (male only); Uncommon: anorgasmia, breast pain, sexual dysfunction (occasionally persisting after treatment discontinuation); Rare: priapism (male only).

The same text also says4.8 Undesirable effects · b. Adverse reactions from clinical trialsIt is important to emphasise that, although the events reported did occur during treatment with fluoxetine, they were not necessarily caused by it.

The originator product is not in the list we read. This is another product from that list.

This sentence stands in the list of adverse reactions. The warnings section of this text has no entry on sexual function.

A table cell or list line is shown whole, as the text prints it. Some of them also name side effects that are not sexual.

Text for professionals New Zealand Data Sheet, Arrow - FluoxetineArrow - Fluoxetine 20 mg capsules, Teva Pharma (New Zealand) Limited · Read in the regulator's own database: MedsafeAlso on record: 1 more text for professionals, with such a sentence; 2 patients' leaflets, with such a sentenceText revisedChecked
Germany

Sexual side effects that continue after stopping4.4 Besondere Warnhinweise und Vorsichtsmaßnahmen für die Anwendung · Sexuelle FunktionsstörungEs wurden lang anhaltende sexuelle Funktionsstörungen berichtet, bei denen die Symptome trotz der Absetzung von SSRI bestehen blieben.Original text: German. Our translation:Long-lasting sexual dysfunction has been reported in which the symptoms continued despite the SSRI being stopped.

Sexual side effects, as listed4.8 Nebenwirkungen · Psychiatrische Erkrankungen · HäufigAngst, Nervosität Ruhelosigkeit Angespanntheit verminderte Libido3 Schlafstörung abnormale Träume4Original text: German. Our translation:Anxiety, nervousness restlessness tension decreased libido3 sleep disorder abnormal dreams4

Sexual side effects, as listed4.8 Nebenwirkungen · Psychiatrische Erkrankungen · GelegentlichDepersonalisation, gehobene Stimmung, euphorische Stimmung, abnormales Denken abnormaler Orgasmus5 Zähneknirschen, suizidale Gedanken und suizidales Verhalten6Original text: German. Our translation:Depersonalisation, elevated mood, euphoric mood, abnormal thinking abnormal orgasm5 teeth grinding, suicidal thoughts and suicidal behaviour6

Sexual side effects, as listed4.8 Nebenwirkungen · Erkrankungen der Geschlechtsorgane und der Brustdrüse · Häufiggynäkologische Blutung14 Erektile Dysfunktion Ejakulationsstörung15Original text: German. Our translation:gynaecological bleeding14 Erectile dysfunction Ejaculation disorder15

Sexual side effects, as listed4.8 Nebenwirkungen · Erkrankungen der Geschlechtsorgane und der Brustdrüse · Gelegentlichsexuelle Dysfunktion16Original text: German. Our translation:sexual dysfunction16

Sexual side effects that continue after stopping4.8 Nebenwirkungen · Tabellarische Zusammenfassung der Nebenwirkungen · Fußnote 16Gelegentlich anhaltend nach Absetzung der TherapieOriginal text: German. Our translation:Occasionally persisting after the therapy is stopped

Sexual side effects, as listed4.8 Nebenwirkungen · Erkrankungen der Geschlechtsorgane und der Brustdrüse · SeltenGalaktorrhoe, Hyperprolaktinämie, PriapismusOriginal text: German. Our translation:Galactorrhoea, hyperprolactinaemia, priapism

The same text also says4.8 Nebenwirkungen · Zusammenfassung des SicherheitsprofilsSchweregrad und Häufigkeit von Nebenwirkungen können im Verlauf der Behandlung abnehmen und führen im Allgemeinen nicht zu einem Abbruch der Behandlung.Original text: German. Our translation:The severity and frequency of side effects may decrease in the course of treatment and do not generally lead to treatment being stopped.

Sexual side effects, as listed4.8 Nebenwirkungen · Kinder und JugendlicheEinzelfälle von Nebenwirkungen, die möglicherweise auf eine verzögerte sexuelle Entwicklung oder Störung der Sexualfunktion hinweisen, wurden während der klinischen Anwendung bei Kindern und Jugendlichen berichtet (siehe auch Abschnitt 5.3).Original text: German. Our translation:Isolated cases of side effects that may point to delayed sexual development or a disorder of sexual function were reported during clinical use in children and adolescents (see also section 5.3).

This is the holder's own copy. The regulator's database asks visitors to accept its terms first, which we did not do.

The originator product's text could not be opened. This is the text of another product, the one named in this row.

A table cell or list line is shown whole, as the text prints it. Some of them also name side effects that are not sexual.

Text for professionals FachinformationFluoxetin-ratiopharm® 20 mg Hartkapseln, ratiopharm GmbH · Read on the holder's own site: ratiopharm GmbHAlso on record: 1 more text for professionals, could not be opened; patients' leaflet, with such a sentence; patients' leaflet, could not be opened; related document, with such a sentenceText revisedChecked
France

Sexual side effects that continue after stopping4.4. Mises en garde spéciales et précautions d'emploi · Dysfonction sexuelleDes cas de dysfonction sexuelle dont les symptômes se sont prolongés malgré l’arrêt du traitement par des ISRS ont été rapportés.Original text: French. Our translation:Cases of sexual dysfunction in which the symptoms continued despite stopping treatment with SSRIs have been reported.

Sexual side effects, as listed4.8. Effets indésirables · Affections psychiatriques · FréquentAnxiété. Nervosité. Impatiences. Tension. Baisse de la libido3. Troubles du sommeil. Rêves anormaux4.Original text: French. Our translation:Anxiety. Nervousness. Restlessness. Tension. Decreased libido3. Sleep disorders. Abnormal dreams4.

Sexual side effects, as listed4.8. Effets indésirables · Affections psychiatriques · Peu fréquentDépersonnalisation. Exaltation. Euphorie. Pensées anormales. Orgasmes anormaux5. Bruxisme. Pensées et comportement suicidaires6.Original text: French. Our translation:Depersonalisation. Elation. Euphoria. Abnormal thoughts. Abnormal orgasms5. Bruxism. Suicidal thoughts and behaviour6.

Sexual side effects, as listed4.8. Effets indésirables · Affections des organes de reproduction et du sein · FréquentSaignements gynécologiques14. Dysfonction érectile. Troubles de l’éjaculation15.Original text: French. Our translation:Gynaecological bleeding14. Erectile dysfunction. Ejaculation disorders15.

Sexual side effects, as listed4.8. Effets indésirables · Affections des organes de reproduction et du sein · Peu fréquentTroubles sexuels16.Original text: French. Our translation:Sexual disorders16.

Sexual side effects that continue after stopping4.8. Effets indésirables · b. Tableau récapitulatif des effets indésirables · note 16Pouvant parfois persister après arrêt du traitementOriginal text: French. Our translation:May sometimes persist after treatment is stopped

Sexual side effects, as listed4.8. Effets indésirables · Affections des organes de reproduction et du sein · RareGalactorrhée. Hyperprolactinémie Priapisme.Original text: French. Our translation:Galactorrhoea. Hyperprolactinaemia Priapism.

The same text also says4.8. Effets indésirables · a. Résumé du profil de sécuritéLes effets indésirables peuvent diminuer en intensité et en fréquence lors de la poursuite du traitement et ne nécessitent généralement pas l’arrêt du traitement.Original text: French. Our translation:The adverse effects may decrease in intensity and frequency as treatment continues and do not generally require treatment to be stopped.

Sexual side effects, as listed4.8. Effets indésirables · d. Population pédiatriqueDes cas isolés d’effets indésirables suggérant des retards de maturation sexuelle ou une dysfonction sexuelle ont été rapportés lors de l’utilisation clinique en pédiatrie (voir également rubrique 5.3).Original text: French. Our translation:Isolated cases of adverse effects suggesting delayed sexual maturation or sexual dysfunction have been reported during paediatric clinical use (see also section 5.3).

The text itself prints no date of revision.

An official list of medicines we read shows this product as discontinued or no longer marketed, and the text in this row is still this product's own.

Texts for other products in this country do not all say the same. The ones we read are on the full record.

A table cell or list line is shown whole, as the text prints it. Some of them also name side effects that are not sexual.

Text for professionals Résumé des Caractéristiques du ProduitPROZAC 20 mg, gélule, LILLY France · Read in the government's medicines database: Base de données publique des médicamentsAlso on record: 1 more text for professionals, with such a sentence; 2 patients' leaflets, with such a sentenceUpdated by the regulatorChecked
Italy

Sexual side effects that continue after stopping4.4 Avvertenze speciali e precauzioni di impiego · Disfunzione sessualeSono stati segnalati casi di disfunzione sessuale a lungo termine con persistenza dei sintomi dopo l’interruzione dell’uso di SSRI.Original text: Italian. Our translation:Cases of long-term sexual dysfunction have been reported, with the symptoms persisting after the use of SSRIs was stopped.

Sexual side effects, as listed4.8 Effetti indesiderati · b. Tabella riassuntiva delle reazioni avverse · Disturbi psichiatrici · ComuneAnsia Nervosismo Irrequietezza Tensione Diminuzione della libido3 Disturbi del sonno Sogni anormali4Original text: Italian. Our translation:Anxiety Nervousness Restlessness Tension Decreased libido3 Sleep disorders Abnormal dreams4

Sexual side effects, as listed4.8 Effetti indesiderati · b. Tabella riassuntiva delle reazioni avverse · Disturbi psichiatrici · Non comuneDepersonalizzazione Umore elevato Umore euforico Pensiero anormale Orgasmo anormale5 Bruxismo Ideazioni e comportamento suicidario6Original text: Italian. Our translation:Depersonalisation Elevated mood Euphoric mood Abnormal thinking Abnormal orgasm5 Bruxism Suicidal ideation and behaviour6

Sexual side effects, as listed4.8 Effetti indesiderati · b. Tabella riassuntiva delle reazioni avverse · Patologie dell'apparato riproduttivo e della mammella · ComuneSanguinamento a carico dell'apparato riproduttivo femminile14 Disfunzione erettile Disturbo dell’eiaculazione15Original text: Italian. Our translation:Bleeding of the female reproductive system14 Erectile dysfunction Ejaculation disorder15

Sexual side effects, as listed4.8 Effetti indesiderati · b. Tabella riassuntiva delle reazioni avverse · Patologie dell'apparato riproduttivo e della mammella · Non comuneDisfunzione di natura sessuale16Original text: Italian. Our translation:Dysfunction of a sexual nature16

Sexual side effects that continue after stopping4.8 Effetti indesiderati · b. Tabella riassuntiva delle reazioni avverse · nota 16Occasionalmente persistente dopo sospensione del trattamento.Original text: Italian. Our translation:Occasionally persistent after treatment is stopped.

Sexual side effects, as listed4.8 Effetti indesiderati · b. Tabella riassuntiva delle reazioni avverse · Patologie dell'apparato riproduttivo e della mammella · RaroGalattorrea Iperprolattinemia PriapismoOriginal text: Italian. Our translation:Galactorrhoea Hyperprolactinaemia Priapism

The same text also says4.8 Effetti indesiderati · a. Sommario del profilo di sicurezzaGli effetti indesiderati possono diminuire di intensità e frequenza con il trattamento continuato e generalmente non portano ad una interruzione della terapia.Original text: Italian. Our translation:The undesirable effects may decrease in intensity and frequency with continued treatment and do not generally lead to therapy being stopped.

Sexual side effects, as listed4.8 Effetti indesiderati · d. Popolazione pediatrica (vedere paragrafi 4.4 e 5.1)Nell’impiego clinico in pediatria sono stati riportati casi isolati di eventi avversi potenzialmente indicanti una ritardata maturazione sessuale o una disfunzione sessuale (vedere anche paragrafo 5.3).Original text: Italian. Our translation:In paediatric clinical use, isolated cases have been reported of adverse events potentially indicating delayed sexual maturation or sexual dysfunction (see also section 5.3).

The text itself prints no date of revision.

An official list of medicines we read shows this product as discontinued or no longer marketed, and the text in this row is still this product's own.

Texts for other products in this country do not all say the same. The ones we read are on the full record.

A table cell or list line is shown whole, as the text prints it. Some of them also name side effects that are not sexual.

Text for professionals Riassunto delle caratteristiche del prodottoProzac 20 mg capsule rigide, Eli Lilly Italia S.p.A. · Read in the regulator's own database: Banca Dati FarmaciAlso on record: 1 more text for professionals, with such a sentence; 2 patients' leaflets, with such a sentenceMade available by the regulatorChecked
Spain

Sexual side effects that continue after stopping4.4. Advertencias y precauciones especiales de empleo · Disfunción sexualSe han notificado casos de disfunción sexual de larga duración en los que los síntomas persisten a pesar de la suspensión del ISRS.Original text: Spanish. Our translation:Cases of long-lasting sexual dysfunction have been reported in which the symptoms persist despite the SSRI being stopped.

Sexual side effects, as listed4.8. Reacciones adversas · Resumen tabulado de reacciones adversas · Trastornos psiquiátricos · FrecuentesAnsiedad Nerviosismo Inquietud Tensión Disminución de la libido3 Trastornos del sueño Sueños anormales4Original text: Spanish. Our translation:Anxiety Nervousness Restlessness Tension Decreased libido3 Sleep disorders Abnormal dreams4

Sexual side effects, as listed4.8. Reacciones adversas · Resumen tabulado de reacciones adversas · Trastornos psiquiátricos · Poco frecuentesDespersonalización Estado elevado del ánimo Estado eufórico del ánimo Pensamiento anormal Orgasmo normal5 Bruxismo Comportamientos y pensamientos suicidas6Original text: Spanish. Our translation:Depersonalisation Elevated mood Euphoric mood Abnormal thinking Abnormal orgasm5 Bruxism Suicidal behaviour and thoughts6

Sexual side effects, as listed4.8. Reacciones adversas · Resumen tabulado de reacciones adversas · Trastornos del aparato reproductor y de la mama · FrecuentesHemorragia ginecológica14 Disfunción eréctil Trastorno de la eyaculación15Original text: Spanish. Our translation:Gynaecological bleeding14 Erectile dysfunction Ejaculation disorder15

Sexual side effects, as listed4.8. Reacciones adversas · Resumen tabulado de reacciones adversas · Trastornos del aparato reproductor y de la mama · Poco frecuentesDisfunción sexualOriginal text: Spanish. Our translation:Sexual dysfunction

Sexual side effects, as listed4.8. Reacciones adversas · Resumen tabulado de reacciones adversas · Trastornos del aparato reproductor y de la mama · RarasGalactorrea Hiperprolactinemia PriapismoOriginal text: Spanish. Our translation:Galactorrhoea Hyperprolactinaemia Priapism

The same text also says4.8. Reacciones adversas · Resumen del perfil de seguridadLas reacciones adversas pueden disminuir en intensidad y frecuencia con el tratamiento continuado y no conducen generalmente a la interrupción del tratamiento.Original text: Spanish. Our translation:The adverse reactions may decrease in intensity and frequency with continued treatment and do not generally lead to treatment being stopped.

Sexual side effects, as listed4.8. Reacciones adversas · Población pediátrica (ver secciones 4.4 y 5.1)Han sido notificados de la experiencia clínica en pediatría casos aislados de efectos adversos indicando potencialmente un retraso en la maduración sexual o disfunción sexual (ver también sección 5.3).Original text: Spanish. Our translation:From clinical experience in children, isolated cases have been reported of adverse effects potentially indicating delayed sexual maturation or sexual dysfunction (see also section 5.3).

An official list of medicines we read shows the originator product as cancelled, revoked or archived. This is the text of another product, the one named in this row.

Texts for other products in this country do not all say the same. We searched them for sentences about sexual side effects continuing after stopping and did not read them whole. This row shows the product named, and no other.

Spelling and punctuation are the document's own.

A table cell or list line is shown whole, as the text prints it. Some of them also name side effects that are not sexual.

Text for professionals Ficha técnicafluoxetina cinfa 20 mg cápsulas duras EFG, Laboratorios Cinfa, S.A. · Read in the regulator's own database: CIMAAlso on record: patients' leaflet, with such a sentence; related document, with such a sentenceText revisedChecked
Brazil

Sexual side effects, as listed9. REAÇÕES ADVERSAS · Reação comum (> 1/100 e < 1/10):diminuição da libido (incluindo perda da libido)Original text: Portuguese. Our translation:decreased libido (including loss of libido)

Sexual side effects, as listed9. REAÇÕES ADVERSAS · Reação comum (> 1/100 e < 1/10):distúrbios da ejaculação (incluindo falha na ejaculação, disfunção da ejaculação, ejaculação precoce, retardo na ejaculação e ejaculação retrógrada)Original text: Portuguese. Our translation:ejaculation disorders (including ejaculation failure, ejaculation dysfunction, premature ejaculation, delayed ejaculation and retrograde ejaculation)

Sexual side effects, as listed9. REAÇÕES ADVERSAS · Reação comum (> 1/100 e < 1/10):disfunção erétilOriginal text: Portuguese. Our translation:erectile dysfunction

Sexual side effects, as listed9. REAÇÕES ADVERSAS · Reação incomum (> 1/1.000 e <1/100):alteração do orgasmo (incluindo anorgasmia)Original text: Portuguese. Our translation:change in orgasm (including anorgasmia)

Sexual side effects, as listed9. REAÇÕES ADVERSAS · Reação incomum (> 1/1.000 e <1/100):aumento da libidoOriginal text: Portuguese. Our translation:increased libido

Sexual side effects, as listed9. REAÇÕES ADVERSAS · Relatos pós-comercialização:priapismoOriginal text: Portuguese. Our translation:priapism

Sexual side effects that continue after stopping9. REAÇÕES ADVERSAS · Relatos pós-comercialização:disfunção sexual (ocasionalmente persistindo após a descontinuação do uso)Original text: Portuguese. Our translation:sexual dysfunction (occasionally persisting after use is stopped)

This is the holder's own copy. The regulator's database refused our requests (it blocks by country; we asked from Denmark).

The originator product's text could not be opened. This is the text of another product, the one named in this row.

Text for professionals Fluoxetin (cloridrato de fluoxetina): bula para o profissional de saúdeFluoxetin cápsula dura 20 mg, Cristália Produtos Químicos Farmacêuticos Ltda. · Read on the holder's own site: Cristália Produtos Químicos Farmacêuticos Ltda.Also on record: 1 more text for professionals, could not be opened; patients' leaflet, with such a sentence; patients' leaflet, could not be openedThe text prints no dateChecked
India

We could not open this text on 14 October 2026: this regulator publishes no database of such texts. This says nothing about what the text contains.

Text for professionalsWe tried: cdsco.gov.in/opencms/opencms/en/Notifications/Prescribing-Information/Tried

Brand names

These are the brand names of fluoxetine we saw in the official lists, compendia and regulators' pages we opened on or after 14 October 2026. A country may have more.

Prozac
United States, France, Italy
Olena
United Kingdom
Prozep
United Kingdom
Fluox
New Zealand
Fluoxeren
Italy
Xeredien
Italy
Luramon
Spain
Daforin
Brazil
Fluoxetin
Brazil
Fluxene
Brazil
Prozen
Brazil
Verotina
Brazil
Zyfloxin
Brazil

What is not known

  • No reliable figure exists for how often PSSD happens. (source)
  • One study of health records gives an estimate for men, counted through prescriptions for erection medicines. (source)
  • It is not known how many people fully recover. (source)
  • None of the product texts we read says how long the sexual dysfunction can last. (source)

Code and reporting

In a report to a medicines regulator, the term is Post-SSRI sexual dysfunction (MedDRA code 10086208). Where to report, country by country

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