The Milano Project

Donate to Research That Brings Real Hope

For years, PFS and PSSD patients have searched for answers. Now, scientists at the University of Milan are uncovering the biological foundations of these conditions — bringing validation, understanding, and solutions.

Watch the documentary Donate now

The Milano Project

Donate to Research That Brings Real Hope

Watch the documentary Donate now

Help Turn Research Into Treatment

Your support will accelerate the most advanced research into PFS and PSSD — conditions long ignored, now finally understood at the biological level.

Real science, real progress – Led by Prof. Roberto Melcangi at the University of Milan, uncovering hormonal, neurosteroid, and genetic disruptions.
Shared pathways, shared solutions – Studying PFS and PSSD side by side to identify what drives both conditions — and how to reverse it.
Hope backed by data – Results are already shaping new diagnostic tools and potential treatment strategies.
Patient-driven change – Funded by those who live it, pushing research where institutions have failed.

Every donation fuels tangible breakthroughs — and a future where recovery becomes possible.

Help Turn Research Into Treatment

Your support will accelerate the most advanced research into PFS and PSSD — conditions long ignored, now finally understood at the biological level.

Real science, real progress – Led by Prof. Roberto Melcangi at the University of Milan, uncovering hormonal, neurosteroid, and genetic disruptions.
Shared pathways, shared solutions – Studying PFS and PSSD side by side to identify what drives both conditions — and how to reverse it.
Hope backed by data – Results are already shaping new diagnostic tools and potential treatment strategies.
Patient-driven change – Funded by those who live it, pushing research where institutions have failed.

Every donation fuels tangible breakthroughs — and a future where recovery becomes possible.

Published Milano Project Studies

1 out of 7 studies published

Results From Study 1

Allopregnanolone Alleviates Some Symptoms of Finasteride-induced Inflammation in Both the Gut and Hypothalamus of Rats, First Milano Project Study Demonstrates

The study shows that finasteride withdrawal triggers inflammation in both gut and hypothalamus in rats, and that allopregnanolone (ALLO) can reverse several of these effects, including restoring the potential PFS biomarker PPAR-α. This is the first demonstration of a mechanistic pathway that can be targeted and partially normalised. It confirms gut–brain disruption in PFS, identifies a viable treatment candidate, and moves the Milano Project closer to real therapeutic options for patients.

A Mission to Accelerate Real Results

The Milano Project aims to:

Complete 7 human investigations on PFS and PSSD by the end of 2026
Identify biomarkers proving the biological basis of these conditions
Map how finasteride and SSRIs disrupt neurosteroid synthesis, including allopregnanolone
Build the foundation for human clinical trials in Italy
Share all data with qualified researchers worldwide

“We are no longer in the dark. The evidence is strong
— and the next step is human clinical trials.”
— Prof. Roberto Melcangi

Inside the Milano Project

Join Robb as he travels to Italy to meet Professor Melcangi and his team.
Step inside the lab, meet the PhD students running advanced neurosteroid and molecular assays — and hear directly from the scientists behind this historic effort.

“This is not theory — it’s real science happening right now.”
— Robb, SIDEfxHUB

Committed to the Science — and the People Living With PFS & PSSD

The Milano Project represents a collaboration built on integrity, expertise, and genuine commitment — a team whose dedication to understanding PFS and PSSD is both scientific and deeply human.

For over a decade, they have worked quietly and rigorously to uncover the biological mechanisms behind these conditions, driven not by recognition but by responsibility. Their research stands as a beacon of hope for a community that has long been overlooked.

Watch the documentary Donate now

Other Ongoing Research Projects

Support ongoing research into PFS & PSSD. As a neutral charity, we facilitate direct donations to research studies and provide links to other relevant websites, where appropriate. Thank you for your consideration.