UK patient charity · PFS, PSSD & PAS Millions take these drugs.
Thousands are left with permanent disease.
- Finasteride, antidepressants, isotretinoin.
- They can cause life-altering, irreversible conditions.
- We fight for recognition, and fund the research to end it.
Three drugs. One pattern.
PFS
Finasteride / PropeciaA hair-loss pill. Lasting sexual, cognitive and mood damage.
About PFS →PSSD
SSRIs / AntidepressantsLasting genital numbness and emotional blunting, often after stopping.
About PSSD →PAS
Isotretinoin / AccutaneAn acne drug, mostly given to teenagers. Lasting sexual and psychiatric damage.
About PAS → 550+ people have joined the registry.
Join them.
- Put your condition on the record
- Be first to hear about studies you can join
- Help researchers find people like you
- 3 minutes to sign up
- Information never shared
PFS / PAS / PSSD Summit 2026
In April 2026, Dr. Kenneth Peters held the first medical conference on PFS, PAS and PSSD together. Urologists (doctors for the bladder and sex organs), researchers and patients were in the same room.
From evidence to treatment
Professor Roberto Melcangi’s team in Milan is finding out what these drugs change in the body.
The next step is testing in people.
“We are no longer in the dark. The evidence is strong. Now we need to take the next step.”
University of Milan
What is being reported
Amanda's story: 6 years on Lexapro
Amanda, a nurse in the United States, was prescribed escitalopram at 22 and took it for 6 years.
Read more →
Andy's story: 13 years after citalopram
Andy was prescribed citalopram at 23. He describes symptoms that have lasted more than 13 years and go far beyond sexual dysfunction.
Read more →
Anthony's story: 11 pills of sertraline
Anthony took 11 pills of sertraline (Zoloft) for mild insomnia. Within days, he says, he felt emotionally numb.
Read more →You do not have to work this out alone
Reporting a side effect+
How to report to the MHRA Yellow Card scheme, the FDA, or your own national regulator. And why your report matters.
WhatsApp peer support groups+
Four small, private groups for people living with PFS and PSSD. The groups are UK, Scandinavia, Benelux/France/Italy, and US/Canada. They are for people on our registry.
Patient support library+
Guides, ways to cope, and what to bring to an appointment. Written for PFS and PSSD.
Nothing here is medical advice
Do not stop a prescription without speaking to your prescriber. Stopping suddenly carries its own risks. If you are in crisis, the helplines at the foot of this page are answered any hour.