The side effects that never stopped
- Hair-loss, antidepressant and acne drugs — taken by millions.
- For some, the side effects never stop, long after the last dose.
- We fund the research to end them — and fight to get them recognised.
Three medicines. The same story.
Finasteride for hair loss. Isotretinoin for acne. SSRIs for depression. Different drugs, one pattern — and for some people it does not end when the prescription does.
Post-Finasteride Syndrome
Finasteride / PropeciaPrescribed for male pattern hair loss and enlarged prostate. A minority of patients report sexual, cognitive and emotional symptoms that persist after stopping.
Read the evidence →PSSD
SSRIs / AntidepressantsAmong the world’s most prescribed antidepressants. Some patients experience persistent sexual dysfunction and emotional blunting that continues after treatment ends.
Read the evidence →Post-Accutane Syndrome
Isotretinoin / AccutanePrescribed for severe acne. Some patients report sexual, cognitive and emotional symptoms that continue long after the course is completed.
Read the evidence →
Where the answers are coming from
At the University of Milan, Professor Roberto Melcangi’s team is uncovering the biology behind PFS and PSSD — the most thorough programme ever run on these conditions, and the closest anyone has come to a treatment.
“We are no longer in the dark. The evidence is strong — and the next step is human clinical trials.”
University of Milan
Help build the evidence
The registry is what turns individual accounts into something researchers and regulators can act on. It takes about three minutes, and you can stay anonymous.
You do not have to work this out alone
WhatsApp peer support groups+
Four small, private groups for people living with PFS and PSSD — UK, Scandinavia, Benelux/France/Italy, and US/Canada. They are for people on our registry.
Patient support library+
Guides, coping strategies and what to bring to an appointment, written for PFS and PSSD specifically.
Reporting a side effect+
How to file with the MHRA Yellow Card scheme, the FDA, or your own national regulator — and why it matters that you do.
Nothing here is medical advice
Do not stop a prescription without speaking to your prescriber — stopping abruptly carries its own risks. If you are in crisis, the helplines at the foot of this page are answered any hour.