Millions take these drugs.
Thousands are left with permanent disease.
- Finasteride, SSRIs, isotretinoin.
- They can cause life-altering, irreversible conditions.
- We fight for recognition, and fund the research to end it.
Three drugs. One pattern.
PFS
Finasteride / PropeciaA hair-loss pill. Lasting sexual, cognitive and mood damage.
About PFS →PSSD
SSRIs / AntidepressantsLasting genital numbness and emotional blunting, often after stopping.
About PSSD →PAS
Isotretinoin / AccutaneAn acne drug, mostly given to teenagers. Lasting sexual and psychiatric damage.
About PAS →PFS / PAS / PSSD Summit 2026
In April 2026, Dr. Kenneth Peters held the first medical conference on PFS, PAS and PSSD together. Urologists (doctors for the bladder and sex organs), researchers and patients were in the same room.
From evidence to treatment
Professor Roberto Melcangi’s team in Milan is finding out what these drugs change in the body.
The next step is testing in people.
“We are no longer in the dark. The evidence is strong. Now we need to take the next step.”
University of Milan
Help build the evidence
The registry turns single stories into numbers that researchers and regulators can use. It takes about 3 minutes. You can stay anonymous.
What is being reported
Emotional blunting on antidepressants
Around 46% of people on antidepressants report emotional blunting. The research shows it is separable from the depression itself.
Read more →
What the MHRA, EMA and FDA say about PSSD
Three medicines regulators have added persistent sexual dysfunction to SSRI labels. The FDA has not, and is being sued over it.
Read more →
Which antidepressants are linked to PSSD?
The warning about persistent sexual dysfunction was added to every SSRI and SNRI, not to one drug. Here is the full list, and what we cannot tell you.
Read more →You do not have to work this out alone
Reporting a side effect+
How to report to the MHRA Yellow Card scheme, the FDA, or your own national regulator. And why your report matters.
WhatsApp peer support groups+
Four small, private groups for people living with PFS and PSSD. The groups are UK, Scandinavia, Benelux/France/Italy, and US/Canada. They are for people on our registry.
Patient support library+
Guides, ways to cope, and what to bring to an appointment. Written for PFS and PSSD.
Nothing here is medical advice
Do not stop a prescription without speaking to your prescriber. Stopping suddenly carries its own risks. If you are in crisis, the helplines at the foot of this page are answered any hour.